With grape pomace coming from winery by-product as material,cellulose was used to active dietary fibre in grape pomace to improve its content of soluble dietary fibre.Through single factors and orthogonal experiments,the optimal reaction conditions were obtained as follows,pH was 5.0,diluted cellulose dosage was 12.5mL(5U/mL),temperature was 40℃,after reacting for 1 hour,grape pomace had the soluble dietary fiber with the highest rate 19.26%,the content of SDF in the production is 95.41%,which can be acted as base material of health food.