胸腺嘧啶
碱基对
鸟嘌呤
核酸的分子结构:脱氧核糖核酸的一种结构
胞嘧啶
DNA
多核苷酸
化学
分子
DNA复制
氢键
立体化学
生物化学
核苷酸
基因
有机化学
作者
Matthew Meselson,Franklin W. Stahl
出处
期刊:Cold Spring Harbor Symposia on Quantitative Biology
[Cold Spring Harbor Laboratory]
日期:1958-01-01
卷期号:23: 9-12
被引量:53
标识
DOI:10.1101/sqb.1958.023.01.004
摘要
According to the proposal of Watson and Crick (1953a), a DNA molecule consists of two polynucleotide chains wound helically about a common axis. The nitrogen base (adenine, guanine, thymine, or cytosine) at each level on one chain is hydrogen-bonded to the base at the same level on the other chain. Structural requirements allow the occurrence of only the hydrogen-bonded base pairs adenine-thymine and guanine-cytosine, resulting in a detailed complementariness between the two chains. The self-complementariness of this structure suggested to its inventors (Watson and Crick, 1953b) a definite and structurally plausible hypothesis for the replication of the DNA molecule. According to this idea, the elementary replicative act is a molecular duplication. The two chains separate, exposing the hydrogen-bonding sites of the bases. Then, in accord with the base-pairing restrictions, each chain serves as a template for the synthesis of its complement. Accordingly, each daughter molecule contains one...
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