In this paper, clarification of Traditional Chinese Medicine extract by ceramic microfiltration membrane was studied. The effect of operating parameters, such as filtration pressure, crossflow velocity on membrane flux was investigated. Fouling mechanism of ceramic microfiltration membrane was analyzed with hydraulic resistance model. Membrane was cleaned by using some chemical agents, and the restorations of flux were satisfactory. The results show ceramic microfiltration technology is a promising new one for clarification of traditional Chinese medicine extract.