生物膜
脂质体
抗菌剂
生物相容性材料
药物输送
纳米技术
化学
微生物学
医学
细菌
生物
材料科学
生物医学工程
遗传学
作者
Zora Rukavina,Željka Vanić
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2016-05-24
卷期号:8 (2): 18-18
被引量:136
标识
DOI:10.3390/pharmaceutics8020018
摘要
Biofilm targeting represents a great challenge for effective antimicrobial therapy.Increased biofilm resistance, even with the elevated concentrations of very potent antimicrobial agents, often leads to failed therapeutic outcome.Application of biocompatible nanomicrobials, particularly liposomally-associated nanomicrobials, presents a promising approach for improved drug delivery to bacterial cells and biofilms.Versatile manipulations of liposomal physicochemical properties, such as the bilayer composition, membrane fluidity, size, surface charge and coating, enable development of liposomes with desired pharmacokinetic and pharmacodynamic profiles.This review attempts to provide an unbiased overview of investigations of liposomes destined to treat bacterial biofilms.Different strategies including the recent advancements in liposomal design aiming at eradication of existing biofilms and prevention of biofilm formation, as well as respective limitations, are discussed in more details.
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