缩水甘油
脱氧胆酸
化学
两亲性
壳聚糖
纳米颗粒
核化学
毒品携带者
阿霉素
药物输送
胆酸
组合化学
有机化学
胆汁酸
共聚物
纳米技术
生物化学
材料科学
聚合物
化疗
外科
医学
催化作用
作者
Huofei Zhou,Yu Wu,Xin Guo,Xiudong Liu,Nan Li,Ying Zhang,Xiaojun Ma
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2010-10-28
卷期号:11 (12): 3480-3486
被引量:87
摘要
Novel amphiphilic chitosan derivatives (glycidol−chitosan−deoxycholic acid, G-CS-DCA) were synthesized by grafting hydrophobic moieties, deoxycholic acid (DCA), and hydrophilic moieties, glycidol, with the purpose of preparing carriers for poorly soluble drugs. Based on self-assembly, G-CS-DCA can form nanoparticles with size ranging from 160 to 210 nm, and G-CS-DCA nanoparticles maintained stable structure for about 3 months when stored in PBS (pH 7.4) at room temperature. The critical aggregation concentration decreased from 0.043 mg/mL to 0.013 mg/mL with the increase of degree of substitution (DS) of DCA. Doxorubicin (DOX) could be easily encapsulated into G-CS-DCA nanoparticles and keep a sustained release manner without burst release when exposed to PBS (pH 7.4) at 37 °C. Antitumor efficacy results showed that DOX-G-CS-DCA have significant antitumor activity when MCF-7 cells were incubated with different concentration of DOX-G-CS-DCA nanoparticles. The fluorescence imaging results indicated DOX-G-CS-DCA nanoparticles could easily be uptaken by MCF-7 cells. These results suggested that G-CS-DCA nanoparticles may be a promising carrier for DOX delivery in cancer therapy.
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