Relationship between serum IGF-IIand peripheral neuropathy in type 2 diabetics.

Objective To evaluate the possible relationship between IGF-Ⅱand peripheral neuropathy in type 2 diabetes.Methods Seventy-one type 2 diabetic patients without peripheral neuropathy(Group A),Seventy-seven patients with peripheral neuropathy(Group B)and thiry healthy subjects(Group C)were recruited.Serum IGF-Ⅱwas determined in all subjects.Other clinical parameters(fasting plasma glucose、fasting plasma insulin,et al)and nerve conduction velocity were determined in Group A and Group B.Results Group B had significantly lower levels of IGF-Ⅱ,compared to GroupA and Ⅲ(P0.05).No significant difference was found between Group A and C;the levels of serum IGF-Ⅱ were positively correlated with motor nerves conduction velocity and sensory nerves conduction velocity;IGF-Ⅱwas independently related to peripheral neuropathy in type 2 diabetes.Conclusion Decreased IGF-Ⅱ in type 2 diabetic patients with peripheral neuropathy may contribute to the pathogenesis of neuropathy.