Construction of a polydopamine-MnO2 functionalized metal–organic framework for synergistic photothermal/NO/nanocatalytic antibacterial therapy

In this study, a multifunctional antibacterial platform was constructed that integrates photothermal/ NO/ nanocatalytic therapy by polydopamine (PDA)-MnO2 functionalized metal–organic framework with loading of NO precursor (NO@MOF@ PMnO2). The PDA coating imbues the nanoplatforms with photothermal performance. Furthermore, the heat generated from NIR could trigger a NO release, further augmenting the antibacterial activity. Moreover, the presence of the MnO2 component, which serves as a peroxidase nanozyme, catalyzes the enzymatic decomposition of H2O2 to generate hydroxyl radicals (·OH), increasing the permeability of the bacterial cell membrane and its sensitivity to heat and NO. As a result, the nanoplatform possesses an outstanding antibacterial performance against S. aureus and E. coli under the NIR laser. Therefore, the present study presents a photothermal/NO/nanocatalytic platform for synergistic antibacterial therapy.