医学
维生素D与神经学
维生素D缺乏
优势比
人口
儿科
认知
内科学
环境卫生
精神科
作者
Kahoko Yasumitsu‐Lovell,Lucy Thompson,Elisabeth Fernell,Masamitsu Eitoku,Narufumi Suganuma,Christopher Gillberg
摘要
Abstract Aim While associations between vitamin D deficiency and neurodevelopmental disorders have been found, large studies on child vitamin D, neurodevelopment, and sex differences among the general population are lacking. This study aimed to investigate the association between child serum 25‐hydroxyvitamin D (25(OH)D)) levels and neurodevelopmental problems (NDPs). Methods Serum 25(OH)D and NDPs were measured at age two among the subcohort study of the Japan Environment and Children's Study. NDPs were assessed with the Kyoto Scale of Psychological Development 2001 (Kyoto scale). Adjusted odds ratios (aORs) for the Kyoto‐scale developmental quotient scores <70 were calculated, for postural–motor, cognitive–adaptive, and language–social domains and overall scores, adjusted for test month, latitude, small for gestational age, maternal age, and daycare attendance. Results Among 2363 boys and 2290 girls, boys had higher 25(OH)D levels, but scored lower in the Kyoto scale. For boys in the vitamin D deficiency (<20 ng/mL) group, aORs of scoring the Kyoto‐scale DQs <70 were 2.33 ( p = 0.006) for overall DQs, 1.91 ( p = 0.037) for cognitive–adaptive, and 1.69 ( p = 0.024) for language–social domains. For girls, results were inconclusive. Conclusion Only boys showed a clear and cross‐modal association between vitamin D deficiency and NDPs.
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