Acetaminophen aggravates valproate‐induced hepatic lipid accumulation and apoptosis by facilitating valproate retention

VPA is the main factor contributing to intrahepatic lipid accumulation, but did not induce apoptosis of hepatocytes. APAP inhibited β-oxidation of VPA and caused VPA retention, which aggravated and prolonged the lipid accumulation and finally resulted in hepatocyte apoptosis. We provide evidence and guidance on the use of VPA and APAP in the clinic.