Homochiral Metal‐Organic Framework Membranes for Enantiomer Separation

The purity of a single enantiomer affects human health and safety. Enantiomer membrane separation holds great promise in the field of separation and purification of chiral drugs due to its significant advantages. Homochiral metal-organic framework (HMOF) membranes have been proven feasible for enantiomeric membrane separation and offer a promising solution to break through the bottlenecks faced by traditional enantiomeric membrane separation, thanks to their designable chiral channels, high specific surface area, and continuous operation. This paper provides a comprehensive overview of the research progress of HMOF membranes for enantiomer separation. Starting from the research history of HMOF membranes, this paper reveals the key milestones and driving forces in the development of HMOF membranes. The types of HMOF membranes and their preparation methods are systematically discussed. In addition, an in-depth analysis is conducted on the seperation mechanism and essence of HMOF membranes. Last but not least, the challenges of HMOF membranes are sorted out. At the same time, some views and suggestions are put forward, and the development of HMOF membranes is prospected. It is hoped that this article will contribute a little to the development of this field.