Investigating the fate of Zirconium-89 labelled antibody in cynomolgus macaques

In the non-human primate cynomolgus macaque, ⁸⁹Zr- labelled IgG accumulated in the kidneys and the liver. However, [⁸⁹Zr]Zr-DFO and ⁸⁹Zr did not accumulate in these organs. This preclinical pharmacokinetic study performed with human IgG in a non-human primate model using PET is of great significance as it sheds light on the basic fate and distribution of ⁸⁹Zr- labelled IgG.