工作队
医学
任务(项目管理)
系统性红斑狼疮
重症监护医学
协商一致会议
政治学
病理
内科学
工程类
疾病
公共行政
系统工程
作者
Matteo Piga,Ioannis Parodis,Zahi Touma,Alexandra Legge,Manuel F. Ugarte‐Gil,Ihsane Hmamouchi,José A. Gómez‐Puerta,Hervé Devilliers,Margherita Zen,Jiacai Cho,Nelly Ziadé,Johanna Mücke,Carlos Enrique Toro Gutiérrez,Shinji Izuka,Peter Korsten,Baïdy S.Y. Kane,Vera Golder,Benjamin F. Chong,Guillermo Pons‐Estel,François Chasset
标识
DOI:10.1016/j.autrev.2025.103773
摘要
Implementation of Treat-to-Target (T2T) in routine clinical practice remains low in systemic lupus erythematosus (SLE). Real-world data reveal excessive use of glucocorticoids (GCs) and frequently inadequate disease control. Here, an international task force convened to develop a consensus framework for implementing T2T in routine clinical care of adult patients with SLE. This T2T task force comprised an international panel of 22 physicians involved in the care of SLE and 3 lupus patient research partners. Following a scoping review and online discussions, during which definitions and instruments available for T2T in SLE were examined, the panel developed potential framework statements for implementing T2T in SLE, which were extensively discussed before being agreed upon by Delphi consensus. Additionally, the current challenges of implementing T2T in SLE and how future research may address these issues were analyzed. The framework comprises 5 overarching principles and 11 statements. Despite the absence of formal evidence that T2T offers superiority to conventional SLE management, T2T in SLE has been recommended for over a decade. This task force offers a framework for effectively implementing T2T in SLE from a real-life perspective, informing a wide range of physicians, including those outside the limited circle of lupus specialists.
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