Sustainable and green synthesis of porous organic polymer for solid-phase extraction of four chlorophenols in water and honey

A novel hypercrosslinked polymer (API-HCP) was synthesized using as monomer for the first time. API-HCP exhibited high adsorption affinity toward chlorophenols due to the hydrogen bond, halogen bond and π-stacking interactions. With API-HCP as adsorbent, an efficient solid phase extraction method coupled with high performance liquid chromatography (SPE-HPLC) was established for the sensitive detection of chlorophenols in water and honey samples. Under the optimum conditions, the method provided a good linear response in the range of 0.07-100 ng mL-1 for water and 1.7-500 ng g-1 for honey sample. High sensitivity was achieved, with detection limits (S/N = 3) of 0.02-0.07 ng mL-1 for water and 0.5-1.5 ng g-1 for honey samples. The method recoveries for spiked sample were between 84.0 % and 116.0 %, with relative standard deviations ≤6.1 %. The API-HCP based SPE-HPLC method provided a robust platform for sensitive determination of chlorophenols in water and honey samples.