嵌合抗原受体
遗传增强
计算生物学
计算机科学
免疫系统
生物
神经科学
免疫疗法
免疫学
基因
遗传学
作者
Seung‐Hee Lee,Ahmad S. Khalil,Wilson Wong
出处
期刊:Cell systems
[Elsevier]
日期:2022-11-01
卷期号:13 (11): 864-873
被引量:9
标识
DOI:10.1016/j.cels.2022.09.006
摘要
The success of chimeric antigen receptor (CAR) T cell therapy against hematological cancers has convincingly demonstrated the potential of using genetically engineered cells as therapeutic agents. Although much progress has been achieved in cell therapy, more beneficial capabilities have yet to be fully explored. One of the unique advantages afforded by cell therapies is the possibility to implement genetic control circuits, which enables diverse signal sensing and logical processing for optimal response in the complex tumor microenvironment. In this perspective, we will first outline design considerations for cell therapy control circuits that address clinical demands. We will compare and contrast key design features in some of the latest control circuits developments and conclude by discussing potential future directions.
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