吞噬作用
活性氧
活性氮物种
纳米传感器
氧气
纳米技术
惰性
材料科学
生物物理学
纳米颗粒
化学
微生物学
生物
生物化学
有机化学
作者
Y.X. Qi,F. Zhang,Siyu Tian,Xinwei Zhang,Yi Zhao,Xinwei Zhang,Yan‐Ling Liu,Pingqing Fu,Christian Amatore,Wei‐Hua Huang
标识
DOI:10.1038/s41565-023-01575-0
摘要
Exposure to widely used inert fibrous nanomaterials (for example, glass fibres or carbon nanotubes) may result in asbestos-like lung pathologies, becoming an important environmental and health concern. However, the origin of the pathogenesis of such fibres has not yet been clearly established. Here we report an electrochemical nanosensor that is used to monitor and quantitatively characterize the flux and dynamics of reactive species release during the frustrated phagocytosis of glass nanofibres by single macrophages. We show the existence of an intense prolonged release of reactive oxygen and nitrogen species by single macrophages near their phagocytic cups. This continued massive leakage of reactive oxygen and nitrogen species damages peripheral cells and eventually translates into chronic inflammation and lung injury, as seen during in vitro co-culture and in vivo experiments. Nanofibre lung injury has previously been linked to the leakage of reactive oxygen and nitrogen species in frustrated phagocytosis. Here the authors use a nanosensor to demonstrate, map and track the generation of reactive species during the frustrated phagocytosis of model glass nanofibres.
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