Men with nonobstructive coronary disease have higher burden of ischemic heart disease detected by cardiopulmonary exercise test

Abstract Background Nonobstructive coronary artery disease (NOCAD), characterized by the presence of myocardial ischemic symptoms and signs without obstructive coronaries, is a common clinical condition, but it is less well understood. Few studies have analyzed the gender differences in inducible myocardial ischemia assessed by cardiopulmonary exercise test (CPET) in NOCAD. Methods We conducted a study of 289 NOCAD patients (mean age 60, 56% women) with ischemic symptoms and confirmed ⫹50% coronaries stenoses by coronary angiography who underwent symptom‐limited CPET. We assessed ischemic response using predicted % peak VO 2 , O 2 pulse trajectory, and exercise ECG test. Results Men with NOCAD had significantly lower predicted % peak VO 2 (62% vs. 73%), higher proportions of flattening pattern (16% vs. 2%), and downward patterns of O 2 pulse trajectory (2% vs. 0%) ( p < .0001) compared with women. In contrast, women with NOCAD had a higher prevalence of shallow patterns of O 2 pulse trajectory (21% vs. 6%, p < .0001). Men with NOCAD had a higher risk ischemic profile (medium risk: 63% vs. 54%, high risk: 18% vs. 4%, p < .0001). After adjustment, men with NOCAD had significantly lower predicted % peak VO 2 (β −27.4, 95% CI −30.74 to −24.07), higher risk for abnormal O 2 pulse trajectories (OR 4.21, 95% CI 1.93 to 9.19), and myocardial ischemia risk per CPET parameters (OR 3.14, 95% CI 1.78 to 5.54) ( p < .0001). Conclusion Men with NOCAD had a higher risk profile for ischemic heart disease per CPET. Therefore, they should receive rigorous management and follow‐up to prevent cardiovascular events.