医学
内皮功能障碍
内皮干细胞
内皮素受体
内皮素1
内皮
生物信息学
高血压的病理生理学
血管紧张素II
肾素-血管紧张素系统
血管内皮生长因子B
受体
内科学
血管内皮生长因子
血管内皮生长因子A
血压
生物
体外
血管内皮生长因子受体
生物化学
作者
Gian Paolo Rossi,Matthias Barton,Neeraj Dhaun,Damiano Rizzoni,Teresa Maria Seccia
标识
DOI:10.1097/hjh.0000000000003314
摘要
Endothelial cell function is mediated by different mechanisms in different vascular beds. Moreover, in humans, endothelial cell dysfunction triggers and accelerates the progression of cardiovascular and chronic kidney diseases. Progression of such diseases can be in part mitigated by the control of cardiovascular risk factors and drugs targeting different systems, including endothelin receptor antagonists (ERAs), renin-angiotensin aldosterone antagonists and agents affecting glucose metabolism, all of which were shown to improve endothelial cell function. In recent years, the microRNAs, which are endogenous regulators of gene expression, have been identified as transmitters of information from endothelial cells to vascular smooth muscle cells, suggesting that they can entail tools to assess the endothelial cell dysfunction in arterial hypertension and target for pharmacologic intervention. This article critically reviews current challenges and limitations of available techniques for the invasive and noninvasive assessment of endothelial cell function, and also discusses therapeutic aspects as well as directions for future research in the areas of endothelial cell biology and pathophysiology in humans.
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