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Engineering Multifunctional Thylakoid as an Oxygen Self-Supplying Photosensitizer for Esophageal Squamous Cell Carcinoma-Targeted Photodynamic Therapy

光敏剂 光动力疗法 医学 印度 化学 政治学 光化学 有机化学 中国 法学
作者
Yingqiu Qi,Hui Wang,Anni Du,Chen Liu,Xiaofan Sun,Xiaocao Meng,Jinxiu Shen,Sai‐Yang Zhang,Lirong Zhang,Bing Jiang,Guangjun Nie,Huan Min
出处
期刊:CCS Chemistry [Chinese Chemical Society]
卷期号:5 (11): 2519-2533 被引量:3
标识
DOI:10.31635/ccschem.022.202202404
摘要

Open AccessCCS ChemistryRESEARCH ARTICLES19 Dec 2022Engineering multifunctional thylakoid as an oxygen self-suppling photosensitizer for esophageal squamous cell carcinoma-targeted photodynamic therapy Yingqiu Qi, Hui Wang, Anni Du, Chen Liu, Xiaofan Sun, Xiaocao Meng, Jinxiu Shen, Sai-Yang Zhang, Li-Rong Zhang, Bing Jiang, Guangjun Nie and Huan Min Yingqiu Qi Google Scholar More articles by this author , Hui Wang Google Scholar More articles by this author , Anni Du Google Scholar More articles by this author , Chen Liu Google Scholar More articles by this author , Xiaofan Sun Google Scholar More articles by this author , Xiaocao Meng Google Scholar More articles by this author , Jinxiu Shen Google Scholar More articles by this author , Sai-Yang Zhang Google Scholar More articles by this author , Li-Rong Zhang Google Scholar More articles by this author , Bing Jiang Google Scholar More articles by this author , Guangjun Nie Google Scholar More articles by this author and Huan Min Google Scholar More articles by this author https://doi.org/10.31635/ccschem.022.202202404 SectionsSupplemental MaterialAboutPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinked InEmail Photodynamic therapy (PDT) has emerged as an alternative treatment strategy for esophageal squamous cell carcinoma (ESCC). However, the clinical therapeutic efficiency of PDT is severely limited by poorly targeted photosensitizer delivery, insufficient oxygen supply and neutralization by excessive glutathione (GSH) in tumor tissue. Herein, an engineered multifunctional thylakoid nanostructure, [email protected]@GA (abbreviated as TEPG), composed of a thylakoid membrane (TM) and ESCC cell membrane (EM)-fused biomembrane shell (TM-EM) and gambogic acid (GA)-loaded poly (lactic-co-glycolic acid) nanocore, was designed for enhanced PDT for ESCC. When fused with EM, TM-EM exhibits a tumor targeting advantage due to the homologous affinity of tumor membrane camouflage. The catalase present on TM-EM catalytically decomposes endogenous hydrogen peroxide into oxygen to alleviate hypoxia in the tumor tissue. Moreover, when TEPG was selectively internalized by ESCC cells, GA was released to consume the excessive intracellular GSH. Under infrared irradiation, the PDT effects were enhanced by the self-oxygen supply and GSH scavenging ability provided by TEPG. An in vivo study showed that TEPG effectively induced ESCC tumor cell apoptosis and greatly inhibited the growth of ESCC tumors under infrared irradiation. This study constructed an engineered multifunctional thylakoid-based nanomedicine as an integrated solution to enhance PDT for ESCC. Download figure Download PowerPoint Previous articleNext article FiguresReferencesRelatedDetails Issue AssignmentNot Yet AssignedSupporting Information Copyright & Permissions© 2022 Chinese Chemical Society Downloaded 50 times PDF downloadLoading ...
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