High versus standard radiation dose of definitive concurrent chemoradiotherapy for esophageal cancer: A systematic review and meta-analysis of randomized clinical trials

医学 荟萃分析 食管癌 内科学 随机对照试验 放射治疗 放化疗 肿瘤科 癌症 核医学
作者
Xiaofeng Wang,Hui Bai,Rui Li,Lide Wang,Wencheng Zhang,Jun Liang,Zhiyong Yuan
出处
期刊:Radiotherapy and Oncology [Elsevier BV]
卷期号:180: 109463-109463 被引量:14
标识
DOI:10.1016/j.radonc.2023.109463
摘要

Objectives: Compare the efficacy and safety of high vs standard radiation dose of definitive concurrent chemoradiotherapy (dCCRT) for esophageal cancer (EC). Methods and materials: This meta-analysis is registered in PROSPERO, and it was followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. Eligible randomized clinical trials (RCTs) comparing high dose (HD;≥59.4 Gy/1.8 Gy) and standard doses (SD; 50 Gy/2Gy or 50.4 Gy/1.8 Gy) were identified on electronic databases. STATA16.0 was used for statistical analysis. A meta-analysis was performed to compare treatment effect and toxicity. Results: Four articles with a total of 1014 patients were finally included. The results showed that the two groups had similar 1-, 2-, and 3-year OS rates (RR = 1.08, 95 % CI = 0.90–1.30, P = 0.395; RR = 1.07, 95 % CI = 0.95–1.20, P = 0.272; RR = 1.06, 95 % CI = 0.97–1.17, P = 0.184; respectively) and 2-, and 3-year locoregional progression-free survival (LRPFS) (RR = 0.95, 95 % CI = 0.81–1.10, P = 0.478; RR = 0.97, 95 % CI = 0.85–1.11, P = 0.674; respectively). The HD-RT group had higher grade ≥ 3 treatment-related toxicities (OR = 1.35, 95 % CI = 1.03–1.77, P = 0.029) and treatment-related deaths rates (OR = 1.85, 95 % CI = 1.04–3.28, P = 0.036) compared with the SD-RT group. Results of subgroup analysis also indicated that HD could not bring benefit compared to SD, even with modern radiotherapy techniques. Conclusion: SD-RT had similar treatment effect but lower Grade ≥ 3 treatment-related toxicities rates compared with the HD-RT. Therefore, SD (50 Gy/2Gy or 50.4 Gy/1.8 Gy) should be considered as the recommended dose in dCCRT for EC. Further RCTs are needed to verify our conclusions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ultramantaro完成签到,获得积分10
1秒前
WW完成签到 ,获得积分10
3秒前
pero完成签到,获得积分10
4秒前
科研通AI5应助ultramantaro采纳,获得30
6秒前
两个我完成签到 ,获得积分10
6秒前
6秒前
8秒前
10秒前
qq发布了新的文献求助10
10秒前
YCH完成签到,获得积分10
11秒前
jane发布了新的文献求助10
13秒前
14秒前
啦啦鱼完成签到 ,获得积分10
14秒前
15秒前
lllxxx完成签到 ,获得积分10
17秒前
柚子发布了新的文献求助10
19秒前
研友_VZG7GZ应助爱听歌笑寒采纳,获得10
19秒前
19秒前
shan完成签到,获得积分10
23秒前
23秒前
27秒前
27秒前
Ricardo完成签到 ,获得积分10
27秒前
28秒前
xx发布了新的文献求助10
31秒前
34秒前
renwoxing发布了新的文献求助10
35秒前
38秒前
沉默的半凡完成签到,获得积分10
38秒前
吴千雨完成签到,获得积分10
39秒前
43秒前
44秒前
xiaoxin完成签到,获得积分10
46秒前
47秒前
beyondjun发布了新的文献求助10
48秒前
Ryuki发布了新的文献求助10
50秒前
NexusExplorer应助jcae123采纳,获得10
52秒前
52秒前
renwoxing完成签到,获得积分10
53秒前
鳄鱼蛋完成签到,获得积分10
53秒前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Continuum Thermodynamics and Material Modelling 2000
Encyclopedia of Geology (2nd Edition) 2000
105th Edition CRC Handbook of Chemistry and Physics 1600
Maneuvering of a Damaged Navy Combatant 650
Периодизация спортивной тренировки. Общая теория и её практическое применение 310
Mixing the elements of mass customisation 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3779569
求助须知:如何正确求助?哪些是违规求助? 3325031
关于积分的说明 10221139
捐赠科研通 3040176
什么是DOI,文献DOI怎么找? 1668640
邀请新用户注册赠送积分活动 798728
科研通“疑难数据库(出版商)”最低求助积分说明 758535