纳米探针
化学
荧光
磁共振成像
核磁共振
荧光寿命成像显微镜
纳米技术
碳化
材料科学
光学
医学
物理
放射科
吸附
有机化学
作者
Chang Guo,Qiangqiang Nie,Suying Xu,Leyu Wang
出处
期刊:Analytical Chemistry
[American Chemical Society]
日期:2021-10-09
卷期号:93 (41): 13880-13885
被引量:10
标识
DOI:10.1021/acs.analchem.1c02661
摘要
Dual-modal imaging systems could provide complementary information by taking advantage of each imaging modality. Herein, a fluorescence and 19F magnetic resonance imaging nanoprobe was developed through preparation of 19F-grafted fluorescent carbonized polymer dots (FCPDs). Both fluorescence and 19F nuclear magnetic resonance intensities of these FCPDs can be modulated by controlling the carbonization processes. The strong yellow fluorescence renders these FCPDs capable of cell fluorescence imaging. The in vitro and in vivo assessments demonstrated that the as-prepared FCPDs were suitable for 19F magnetic resonance imaging (19F MRI), which would provide great potential for biological imaging and early diagnosis applications. Moreover, this fabrication strategy offers a new protocol for 19F MRI nanoprobe design.
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