灰质
病理生理学
医学
基于体素的形态计量学
磁共振成像
统计参数映射
儿科
神经科学
病理
白质
心理学
放射科
作者
Steffen Naegel,Julia Zeller,Anders Hougard,Christopher M. Weise,Hans-Christoph-Diener,Stefan Zuelow,Christoph Kleinschnitz,Mark Obermann,K. Solbach,Dagny Holle
出处
期刊:Cephalalgia
[SAGE]
日期:2021-10-04
卷期号:42 (4-5): 335-344
被引量:11
标识
DOI:10.1177/03331024211045653
摘要
To identify grey matter alterations in patients suffering new daily persistent headache to enrich the pathophysiological concept of this rare headache disorder characterised by a distinct, clearly remembered onset and its instant chronification.Magnetic resonance-based voxel-based and surface-based morphometry was used to investigate 23 patients suffering from new daily persistent headache and 23 age- and gender-matched healthy controls with 1.5 Tesla MRI.Independent statistical analysis was performed at three sites using statistical parametric mapping, as well as FSL(FMRIB Software Library)-based approaches.No grey matter changes were detected using this sophisticated and cross-checked method.The absence of structural brain changes in patients with new daily persistent headache contribute to the recent discussion regarding structural alterations in primary headache disorders in general and does not provide evidence for grey matter changes being associated with the pathophysiology of new daily persistent headache. Future research will have to determine the underlying pathophysiological mechanisms of this disorder.
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