细胞周期蛋白依赖激酶
Polo样激酶
激酶
细胞生物学
细胞周期
生物
细胞周期蛋白
细胞分裂
细胞凋亡
细胞
遗传学
作者
Paweł Łukasik,Michał Załuski,Izabela Gutowska
摘要
Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle and transcription, as well as communication, metabolism, and apoptosis. The kinases are organized in a pathway to ensure that, during cell division, each cell accurately replicates its DNA, and ensure its segregation equally between the two daughter cells. Deregulation of any of the stages of the cell cycle or transcription leads to apoptosis but, if uncorrected, can result in a series of diseases, such as cancer, neurodegenerative diseases (Alzheimer’s or Parkinson’s disease), and stroke. This review presents the current state of knowledge about the characteristics of cyclin-dependent kinases as potential pharmacological targets.
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