ATF3 drives cell senescence through TGFβ/Pdcd5 pathway in cardiac myocyte

Recently, we have read an experimental research titled “Muscle-specific programmed cell death 5 deletion attenuates cardiac aging” reported by Naz and his colleagues [ [1] Naz A. Zhang S. An L. et al. Muscle-specific programmed cell death 5 deletion attenuates cardiac aging[J]. Int. J. Cardiol. 2021; 345: 98-104 Abstract Full Text Full Text PDF PubMed Scopus (0) Google Scholar ]. They investigated the role of Pdcd5 in cell senescence and found that Muscle-specific Pdcd5 deficiency alleviates age-related myocardial apoptosis and mitochondrial dysfunction by improving Parkin-mediated mitophagy via p53. However, the potential mechanisms regulating the accumulation of Pdcd5 in aging myocardium need further exploration.