上皮-间质转换
Wnt信号通路
结直肠癌
癌症研究
基因沉默
下调和上调
细胞生长
癌症
恶性肿瘤
大肠癌小鼠模型的建立
信号转导
生物
医学
内科学
转移
细胞生物学
基因
遗传学
作者
Yuzhen Yin,Lili Shi,Jing Yang,Hui Wang,Hang Yang,Qiang Wang
出处
期刊:Bioengineered
[Informa]
日期:2021-12-25
卷期号:13 (1): 107-118
被引量:5
标识
DOI:10.1080/21655979.2021.2009411
摘要
Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract, which has the second highest incidence among gastrointestinal tumors. At present, due to the limitations of current CRC treatment strategies, there is an urgent need for developing more effective therapies. B7 family member H4 (B7-H4) is associated with the progression of a wide spectrum of cancers, but its functional role in CRC is unknown. The purpose of this study is to clarify the role of B7-H4 in CRC and the underlying mechanisms in controlling the progression of CRC. Our data showed that B7-H4 expression in CRC tissues and cell lines was significantly upregulated as compared with normal tissues and normal cell lines. High B7-H4 expression was correlated with a poor prognosis of CRC patients. B7-H4 overexpression promoted the proliferation and invasion of CRC cells, which could be suppressed by Wnt signaling inhibitor. In a mouse xenograft model, silencing B7-H4 suppressed tumor growth and epithelial-mesenchymal transition (EMT) of CRC cells. Collectively, our study demonstrated the oncogenic roles of B7-H4 in regulating the proliferation, EMT as well as the migration of CRC cells through Wnt signaling pathway. The heightened expression of B7-H4 could serve as a prognostic marker for CRC patients.
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