赫拉
药物输送
阿霉素
生物相容性
介孔二氧化硅
材料科学
肿瘤微环境
癌症研究
纳米技术
药品
细胞
靶向给药
生物物理学
化学
药理学
肿瘤细胞
生物
化疗
介孔材料
生物化学
冶金
催化作用
遗传学
作者
Dong Jin-hu,Yao Ma,Rong Li,Wentao Zhang,Meng-Qian Zhang,Fan‐hao Meng,Kai Ding,Haitao Jiang,Yong‐Kuan Gong
标识
DOI:10.1021/acsami.1c14189
摘要
Tumor-targeted delivery and controlled release of antitumor drugs are promising strategies for increasing chemotherapeutic efficacy and reducing adverse effects. Although mesoporous silica nanoparticles (MSNs) have been known as a potential delivery system for doxorubicin (DOX), they have restricted applications due to their uncontrolled leakage and burst release from their large open pores. Herein, we engineered a smart drug-delivery system (smart MSN-drug) based on MSN-drug loading, cell membrane mimetic coating, on-demand pore blocking/opening, and tumor cell targeting strategies. The pore size of DOX-loaded MSNs was narrowed by polydopamine coating, and the pores/channels were blocked with tumor-targeting ligands anchored by tumor environment-rupturable -SS- chains. Furthermore, a cell membrane mimetic surface was constructed to enhance biocompatibility of the smart MSN-drug. Confocal microscopy results demonstrate highly selective uptake (12-fold in comparison with L929 cell) of the smart MSN-drug by HeLa cells and delivery into the HeLa cellular nuclei. Further in vitro IC50 studies showed that the toxicity of the smart MSN-drug to HeLa cells was 4000-fold higher than to the normal fibroblast cells. These exciting results demonstrate the utility of the smart MSN-drug capable of selectively killing tumor cells and saving the normal cells.
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