催化作用
组分(热力学)
化学
氮气
联轴节(管道)
价值(数学)
比例(比率)
组合化学
化学物理
立体化学
生物系统
有机化学
物理
计算机科学
热力学
材料科学
量子力学
机器学习
生物
冶金
作者
Xuexin Liu,Jian Chen,Chunyan Yang,Zhiyan Wu,Zhiyang Li,Yuesen Shi,Tianle Huang,Zhongzhen Yang,Yong Wu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-08-17
卷期号:23 (17): 6831-6835
被引量:13
标识
DOI:10.1021/acs.orglett.1c02392
摘要
Three-component couplings have been realized for efficiently constructing various nitrogen-containing skeletons via C-H activation, where difluorocyclopropenes have been first identified as coupling partners. Many substrates including sp2 and sp3 C-H substrates were well tolerated, furnishing the corresponding products in good yields. Furthermore, a catalyst-dependent reaction was also developed, enabling divergent construction of two different frameworks. The application value of these reactions was demonstrated in gram-scale experiments with as little as 1 mol % catalyst.
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