化学
脂联素
聚糖
体内
肽
生物化学
氨基酸
天然化学连接
生物活性
糖肽
化学合成
功能(生物学)
胰岛素
组合化学
体外
细胞生物学
内分泌学
糖蛋白
胰岛素抵抗
生物技术
抗生素
生物
医学
作者
Huan Wu,Yiwei Zhang,Yuanxin Li,Jinbao Xu,Yu Wang,Xuechen Li
摘要
The homogeneously glycosylated 76-amino acid adiponectin collagenous domains (ACDs) with all of the possible 15 glycoforms have been chemically and individually synthesized using stereoselective glycan synthesis and chemical peptide ligation. The following biological and pharmacological studies enabled correlating glycan pattern to function in the inhibition of cancer cell growth as well as the regulation of systemic energy metabolism. In particular, hAdn-WM6877 was tested in detail with different mouse models and it exhibited promising in vivo antitumor, insulin sensitizing, and hepatoprotective activities. Our studies demonstrated the possibility of using synthetic glycopeptides as the adiponectin downsized mimetic for the development of novel therapeutics to treat diseases associated with deficient adiponectin.
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