釉原蛋白
材料科学
搪瓷漆
生物矿化
无定形磷酸钙
牙釉质
磷灰石
生物物理学
化学工程
结晶学
钙
化学
复合材料
矿物学
冶金
工程类
生物
作者
Dong Wang,Jingjing Deng,Xuliang Deng,Changqing Fang,Xu Zhang,Peng Yang
标识
DOI:10.1002/adma.202002080
摘要
Abstract In situ regeneration of the enamel‐like structure of hydroxyapatite (HAp) crystals under oral conditions is significant for dental caries treatment. However, it is still a challenge for dentists to duplicate the elegant and well‐aligned apatite structure bonding to the surface of demineralized enamel. A biocompatible amelogenin‐inspired matrix, a phase‐transited lysozyme (PTL) film mimicking an N‐terminal amelogenin with central domain (N‐Ame) combined with synthetic peptide (C‐AMG) based on the functional domains of C‐terminal telopeptide (C‐Ame) is shown here, which is formed by amyloid‐like lysozyme aggregation at the enamel interface through a rapid one‐step aqueous coating process. In the PTL/C‐AMG matrix, C‐AMG facilitated the oriented arrangement of amorphous calcium phosphate (ACP) nanoparticles and their transformation to ordered enamel‐like HAp crystals, while PTL served as a strong interfacial anchor to immobilize the C‐AMG peptide and PTL/C‐AMG matrix on versatile substrate surfaces. PTL/C‐AMG film‐coated enamel induced both of the in vivo and in vitro synthesis of HAp crystals, facilitated epitaxial growth of HAp crystals and recovered the highly oriented structure and mechanical properties to levels nearly identical to those of natural enamel. This work underlines the importance of amyloid‐like protein aggregates in the biomineralization of enamel, providing a promising strategy for treating dental caries.
科研通智能强力驱动
Strongly Powered by AbleSci AI