A novel synthesis of 1,1’-(2,4,6-trihydroxy-1,3-phenylene)bis(ethan-1-one) (DAPG) using CuSO4.5H2O as a green catalyst

1,1'-(2,4,6-trihydroxy-1,3-phenylene) bis (ethan-1-one) (DAPG) has been successfully synthesized through Friedel-Craft acylation reaction between phloroglucinol and acetic anhydride in ethyl acetate at room temperature with CuSO4.5H2O catalyst. The CuSO4.5H2O was an environmentally-friendly heterogeneous catalyst. These reactions were carried out in various variations weight of the catalyst, i.e. 20, 25, 30, 35, 40, and 45 mmol. This reaction could be completed in 8-23 hours and produced DAPG compound in good to excellent yields. This product was fully characterized by FT-IR spectroscopy, 1H-NMR, and 13C-NMR.