化学
甲藻
赫拉
细胞毒性T细胞
立体化学
拉伤
二维核磁共振波谱
体外
生物化学
植物
解剖
生物
作者
Masashi Tsuda,Ryui Makihara,Masayuki Tsuda,Takayoshi Suzuki
出处
期刊:Chemical & Pharmaceutical Bulletin
[Pharmaceutical Society of Japan]
日期:2020-09-01
卷期号:68 (9): 864-867
被引量:4
标识
DOI:10.1248/cpb.c20-00329
摘要
Two new macrolides, iriomoteolides-14a (1) and 14b (2) have been isolated from the marine dinoflagellate Amphidinium species (strain KCA09057). Compounds 1 and 2 are 15-membered macrolides, which are structural analogs of amphidinolides O (3) and P (4). The structures of 1 and 2 were assigned on the basis of detailed NMR analyses and chemical conversion studies. Compounds 1 and 2 showed moderate cytotoxic activity against human cervix adenocarcinoma HeLa cells.
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