AB0137 DIVERSITY ANALYSIS OF INTESTINAL FLORA IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Background: Systemic lupus erythematosus (SLE) is a multiple systemic autoimmune disease and its pathogenesis is still not fully understanding. In recent years, there has been reports on the relationship between SLE and intestinal flora. Objectives: To study the diversity and the intestinal flora intestinal microbes in patients with SLE and further provide new ideas for clinical treatment. Methods: The stool samples of 28 patients with SLE and 125 normal healthy adults were collected. The 16S rRNA in the specimen was sequenced using the Roche/45 high-throughput sequencing platform, and the differences between the two groups were compared at the level of the phylum and genus. Results: In SLE patients, as the picture show, the levels of fusobacteria, proteobacteria and TM7 were significantly higher (P<0.05) and the number of firmicutes was significantly decreased (P<0.05) than that of healthy controls at the phylum level.The percentage of bifidobacterium, collinsella, enterococcus, leuconostoc, streptococcus, bilophila were significantly higher (P<0.05) and the number of lachnospira, roseburia, gemmiger, devosia, desulfovibrio were significantly decreased (P<0.05) than that of healthy participants at the genus level. Figure 1. the differences between patients with SLE and normal healthy adults were compared at the level of the phylum Figure 2. the differences between patients with SLE and normal healthy adults were compared at the level of the genus Conclusion: The diversity of intestinal flora in patients with SLE altered from that of normal population. The differences are likely to be one of the pathogenesis of lupus, which might provide theoretical foundation for the regulation of intestinal flora to treat autoimmune diseases such as lupus. Disclosure of Interests: None declared