线粒体
细胞生物学
抗氧化剂
平衡
活性氧
内生
氧化应激
生物
线粒体ROS
生物化学
化学
作者
Salvatore Antonucci,Fabio Di Lisa,Nina Kaludercic
出处
期刊:Cell Calcium
[Elsevier]
日期:2021-03-01
卷期号:94: 102344-102344
被引量:41
标识
DOI:10.1016/j.ceca.2020.102344
摘要
Mitochondrial reactive oxygen species (mROS) are routinely produced at several sites within the organelle. The balance in their formation and elimination is maintained by a complex and robust antioxidant system. mROS may act as second messengers and regulate a number of physiological processes, such as insulin signaling, cell differentiation and proliferation, wound healing, etc. Nevertheless, when a sudden or sustained increase in ROS formation is not efficiently neutralized by the endogenous antioxidant defense system, the detrimental impact of high mROS levels on cell function and viability eventually results in disease development. In this review, we will focus on the dual role of mROS in pathophysiology, emphasizing the physiological role exerted by a regulated mROS production/elimination, and discussing the detrimental effects evoked by an imbalance in mitochondrial redox state. Furthermore, we will touch upon the interplay between mROS and Ca2+ homeostasis.
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