耐受性
医学
疾病
尼罗替尼
安全概况
阿尔茨海默病
不利影响
内科学
酪氨酸激酶
受体
作者
Raymond Scott Turner,Michaeline Hebron,Abigail Lawler,Elizabeth Mundel,Nadia Yusuf,J. Nathan Starr,Muhammad Anjum,Fernando Pagán,Yasar Torres‐Yaghi,Wangke Shi,Sanjana Mulki,Dalila Ferrante,Sara Matar,Xiaoguang Liu,Giuseppe Esposito,Frank E. Berkowitz,Xiong Jiang,Jaeil Ahn,Charbel Moussa
摘要
Preclinical evidence with nilotinib, a US Food and Drug Administration (FDA)-approved drug for leukemia, indicates improvement in Alzheimer's disease phenotypes. We investigated whether nilotinib is safe, and detectable in cerebrospinal fluid, and alters biomarkers and clinical decline in Alzheimer's disease.
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