Allogeneic hematopoietic stem cell transplantation for hemophagocytic syndrome

Hemophagocytic syndrome, also called hemophagocytic lymphohistiocytosis, includes primary hemophagocytic lymphohistiocytosis and secondary hemophagocytic lymphohistiocytosis.Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is the only effective therapy for familial hemophagocytic lymphohistiocytosis (FHL) and refractory EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH), but the differential diagnosis is still difficult.Meanwhile, much more complications and high mortality have attracted attention of many researchers.In this review, the recent advance in allo-HSCT for FHL and EBV-HLH about diagnosis, conditioning regimen, complication after HSCT, death causes and prognosis has been described. Key words: Allogeneic hematopoietic stem cell transplantation; Hemophagocytic lymphohistiocytosis