On the Alkaloids of Aconitum japonicum THUNB. collected at Mt. Mineoka (Chiba Pref.) : Structure Elucidation and Partial Synthesis of a New Alkaloid, 15-α-Hydroxyneoline

We have investigated the alkaloidal constituents of the root of an Aconitum species collected at Mt. Mineoka (Chiba Pref.). In addition to the known nine compounds, i.e. mesaconitine, hypaconitine, aconitine, deoxyaconitine, isotalatizidine, 14-O-acetyltalatizamine, neoline, takaosamine, and ignavine, a new diterpene alkaloid was isolated. The structure of this new base was established to be 15-α-hydroxyneoline by the spectroscopic evidence and by the partial synthesis from neoline.