PLGA公司
生物医学工程
药物输送
材料科学
光热治疗
体内
骨愈合
黑磷
再生(生物学)
骨组织
生物物理学
纳米技术
纳米颗粒
外科
光电子学
医学
生物技术
细胞生物学
生物
作者
Xuzhu Wang,Jundong Shao,Mustafa Abd El Raouf,Hanhan Xie,Hao Huang,Huaiyu Wang,Paul K. Chu,Xue‐Feng Yu,Yang Yang,Abdel Basit Mohamed AbdEl-Aal,Nefissa Helmy Mekkawy,Richard J. Miron,Yufeng Zhang
出处
期刊:Biomaterials
[Elsevier]
日期:2018-10-01
卷期号:179: 164-174
被引量:116
标识
DOI:10.1016/j.biomaterials.2018.06.039
摘要
A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl2 and BP nanosheets (BPs) into poly(lactic-co-glycolic acid) (PLGA) for bone regeneration. The fabricated BP-SrCl2/PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr2+ by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability. Implantation of the BP-SrCl2/PLGA microspheres into a rat femoral defect demonstrates good tissue compatibility and excellent bone regeneration capacity under NIR light irradiation. Our study indicates that local release of Sr2+ at optimal time periods controlled by NIR irradiation improves bone regeneration significantly and this NIR-triggered drug delivery system composed of BPs is suitable for therapies requiring precise control at specific time.
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