甾醇调节元件结合蛋白
脂肪酸合酶
化学
维甲酸
转录因子
细胞生物学
生物
维甲酸受体
转录调控
脂肪生成
脂肪酸合成
作者
Karim Roder,Michael Schweizer
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2007-10-25
卷期号:35 (5): 1211-1214
被引量:14
摘要
A region of the rat FAS (fatty acid synthase) promoter has been defined as being responsible for RA (retinoic acid) responsiveness. The defined promoter region is devoid of canonical RA-response elements but contains cis-elements binding generalized and specific transcription factors that mediate the dietary response of FAS. Our results are consistent with SREBP-1c (sterol-regulatory-element-binding protein 1c) binding in this region, thus bringing about the RA responsiveness of the rat FAS proximal promoter.
科研通智能强力驱动
Strongly Powered by AbleSci AI