Insect salivary effectors disrupt PIEZO1-centric mechanoimmunity against piercing-sucking vectors

fluxes and SA/JA-mediated resistance to promote feeding. Notably, PIEZO1 represents a conserved target of salivary effectors from diverse piercing-sucking insect vectors across both plant and human hosts. Our study unveils the molecular mechanisms underlying host perception of and defense against piercing-sucking insects, pointing to novel strategies against both insects and insect-transmitted diseases.