CaCO 3 -assisted engineering of NIR-II phototheranostics enables photothermally enhanced ferroptosis in cancer through synergistically depleting intracellular glutathione

Ca NPs achieved substantial tumor suppression in mouse models, with a complete remission rate of 80%. This study establishes a facile strategy for developing long-circulating NIR-II phototheranostic agents with self-amplified lipid peroxidation induction capacity, enabling photothermally augmented ferroptosis for cancer therapy.