Orchestrated Photothermal Nanoreactor Promoted Cuproptosis for Synergistic Cancer Therapy Through Glutathione Depletion and Gene Regulation

also reacts with GSH, reducing its inhibitory effect on cuproptosis. The pH-responsive nanoparticle releases components in the tumor niche and features excellent photothermal conversion efficiency for spatiotemporal dual therapy control. Leveraging TNBC cells' high copper metabolic dependence, this strategy selectively induces cancer cell death with minimal normal tissue injury. The results of this study show significant tumor suppression and low systemic toxicity. In summary, our research introduces an innovative metabolic-targeted nanotherapeutic approach, elucidating the synergistic effects between photothermal therapy and copper-mediated mechanisms, which holds potential as a promising strategy for TNBC treatment.