The syntheses of tetrakis(3-hydroxypropyl)methane, tetrakis(3-bromopropyl)methane, tetrakis(3-cyanopropyl)methane, and tetrakis(3-carboxypropyl)methane are described. An abnormal conversion of tetrakis(β-bromoethyl)methane to tris(β-iodoethyl)-β-bromoethylmethane is discussed.