免疫系统
髓源性抑制细胞
脊髓损伤
抑制器
精氨酸酶
神经科学
病变
脊髓
免疫学
医学
T细胞
生物
病理
内科学
癌症
氨基酸
精氨酸
生物化学
作者
Lei Wang,Wei-bo Yu,Tao Luan,Qing Xu
标识
DOI:10.1016/j.jneuroim.2015.11.023
摘要
Spinal cord injury (SCI) is characterized by the loss of motor and sensory functions in areas below the level of the lesion and numerous accompanying deficits. Previous studies have suggested that myeloid-derived suppressor cell (MDSC)-induced immune depression may play a pivotal role in the course of SCI. However, the concrete mechanism of these changes regarding immune suppression remains unknown. Here, we created an SCI mouse model to gain further evidence regarding the relationship between MDSCs following SCI and T lymphocyte suppression. We showed that in the SCI mouse model, the expanding MDSCs have the capacity to suppress T cell proliferation, and this suppression could be reversed by blocking the arginase.
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