胶质瘤
下调和上调
过剩1
癌症研究
细胞凋亡
糖酵解
巴基斯坦卢比
瓦博格效应
细胞生长
葡萄糖转运蛋白
化学
厌氧糖酵解
生物
细胞生物学
酶
生物化学
基因
丙酮酸激酶
内分泌学
胰岛素
作者
Chao Deng,Lipeng Zhang,Qingmin Li
摘要
ABSTRACT F-box protein 17 (FBXO17) is associated with high-grade glioma and acted as a promotor of glioma development. This study investigated the effect and underlying pathway of FBXO17 on glioma. The Cancer Genome Atlas database was applied to analyze FBXO17 expression information in glioma. First, high FBXO17 expressions are associated with glioma and poor prognosis. Then, FBXO17 was upregulated in glioma cells. Meanwhile, knock-down of FBXO17 inhibited cell proliferation, migration, and invasion, but increased the cell apoptosis. Besides, knock-down of FBXO17 inhibited mitochondrial membrane potential and increased reactive oxygen species. Furthermore, knock-down of FBXO17 decreased level of adenosine triphosphate, glucose, lactate, GLUT1, HK2, PFKP, PKM2, and LDHA. In conclusion, FBXO17 was high expression in glioma, and FBXO17 regulates glioma by regulating glycolysis pathway, providing novel theoretical for the treatment of glioma.
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