生物
认知地图
神经科学
人口
放置单元格
空间记忆
背
海马结构
海马体
钙显像
预测(人工智能)
认知
编码(内存)
计算机科学
人工智能
解剖
工作记忆
内科学
医学
环境卫生
钙
作者
Przemysław Jarzębowski,Y. Audrey Hay,Benjamin F. Grewe,Ole Paulsen
出处
期刊:Current Biology
[Elsevier]
日期:2022-02-01
卷期号:32 (4): 834-841.e5
被引量:27
标识
DOI:10.1016/j.cub.2021.12.024
摘要
Hippocampal place cells fire at specific locations in the environment. They form a cognitive map that encodes spatial relations in the environment, including reward locations.1 As part of this encoding, dorsal CA1 (dCA1) place cells accumulate at reward.2-5 The encoding of learned reward location could vary between the dorsal and intermediate hippocampus, which differ in gene expression and cortical and subcortical connectivity.6 While the dorsal hippocampus is critical for spatial navigation, the involvement of intermediate CA1 (iCA1) in spatial navigation might depend on task complexity7 and learning phase.8-10 The intermediate-to-ventral hippocampus regulates reward-seeking,11-15 but little is known about the involvement in reward-directed navigation. Here, we compared the encoding of learned reward locations in dCA1 and iCA1 during spatial navigation. We used calcium imaging with a head-mounted microscope to track the activity of CA1 cells over multiple days during which mice learned different reward locations. In dCA1, the fraction of active place cells increased in anticipation of reward, but the pool of active cells changed with the reward location. In iCA1, the same cells anticipated multiple reward locations. Our results support a model in which the dCA1 cognitive map incorporates a changing population of cells that encodes reward proximity through increased population activity, while iCA1 provides a reward-predictive code through a dedicated subpopulation. Both of these location-invariant codes persisted over time, and together they provide a dual hippocampal reward location code, assisting goal-directed navigation.16,17.
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