丁酰胆碱酯酶
非酒精性脂肪肝
荧光
体内
化学
生物标志物
生物化学
医学
脂肪肝
病理
生物
酶
疾病
乙酰胆碱酯酶
生物技术
阿切
物理
量子力学
作者
Chunbai Xiang,Jingjing Xiang,Yang Xing,Chunbin Li,Lihua Zhou,Daoyong Jiang,Yonglin Peng,Zhen Xu,Guanjun Deng,Baode Zhu,Pengfei Zhang,Lintao Cai,Ping Gong
摘要
Butyrylcholinesterase (BChE) is an essential human biomarker which is related to liver and neurodegenerative diseases. It is of great significance to develop a fluorescent probe that can image BChE in vitro and in vivo. Unfortunately, most fluorescent probes that are based on a single change in fluorescence intensity are susceptible to environmental interference. Therefore, we reported an easily available ratiometric fluorescent probe, TB-BChE, with aggregation-induced emission (AIE) characteristics for ratiometric imaging of BChE. TB-BChE demonstrated excellent sensitivity (LOD = 39.24 ng mL-1) and specificity for BChE. Moreover, we have successfully studied the ratiometric imaging of TB-BChE to BChE in a nonalcoholic fatty liver disease model. These results indicated that TB-BChE is expected to become a powerful analysis tool for butyrylcholinesterase research in basic medicine and clinical applications.
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