Salt Selection

This chapter contains sections titled: Introduction Salt Formation and Polymorphism Target Properties of Active Substances for Drug Products Injectables Solid Dosage Forms Dosage Forms for Other Routes of Application Inhalation Topical Products and the Transdermal Route Basics of Salt Formation Ionization Constant Ionization and pH Solubility Approaches to Salt Screening Initial Data Selection of Salt Formers Automated Salt Screening Selection Procedures and Strategies Points to be Considered Final Decision Salt Form and Life Cycle Management of Drug Products Case Reports Overview of Salt Forms Selected Salt Selection Process Case 1: NVP-BS001 Case 2: NVP-BS002 Discussion and Decision Case 3: NVP-BS003 References