抗生素耐药性
预防性抗生素
阿莫西林
菌尿
抗菌剂
作者
Sudeep Karve,Kellie Ryan,Pascale Peeters,Elisa Baelen,Sonia Rojas-Farreras,Danielle Potter,Jesús Rodríguez-Baño
标识
DOI:10.1016/j.jinf.2017.11.001
摘要
Summary Objectives RECOMMEND (NCT02364284; D42805) assessed treatment patterns and outcomes associated with initial antibiotic therapy (IAT; antibiotics received Methods Data from medical records of hospitalized patients aged ≥18 years with healthcare-associated complicated urinary tract infections (cUTI) are presented. Univariate and multivariate logistic regression analyses identified potential risk factors associated with IAT failure. Results Mean (SD) age was 68.7 (17.4) years (n = 408). In patients with microbiological documentation (357/408), Escherichia coli , Klebsiella pneumoniae and Pseudomonas aeruginosa were most common (47.1%, 21.6% and 11.8%, respectively); 46.1% of patients had a multidrug resistant (MDR) pathogen isolated. Most patients received monotherapy IAT (72.5%). Mean IAT duration was 7.8 days. IAT failure, in-hospital mortality, and mortality 30-day post-discharge were 54.4%, 35.0% and 37.3%, respectively. IAT failure was associated with age, Deyo–Charlson comorbidity score, country, MDR status and ICU admission in the univariate analysis; and country and age in the multivariate analysis. Conclusions This study provides real-world insights into the high rates of IAT failure and morbidity observed in patients with cUTI. Further study is imperative to understand the epidemiology of cUTI, support appropriate IAT selection and management, and reduce the burden of this disease.
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