The Role of Cell Clusters in Intervertebral Disc Degeneration and its Relevance behind Repair

The greatest risk factors for intervertebral disc degeneration are age, spinal level, excessive mechanical loading and genetic inheritance, a major cell-mediated change that occurs during degeneration is increased cell clustering. In fact, cell clusters formations are a histological hallmark behind intervertebral disc degeneration, yet a systematic review focusing on the cell clusters of the intervertebral disc is unknown. Therefore, the main purpose of this article is to discuss the role of cell cluster in intervertebral disc degeneration.