生物
毒力
小泡
分泌物
微生物学
细胞生物学
细菌
细菌外膜
革兰氏阴性菌
利基
病菌
寄主(生物学)
膜
生物化学
大肠杆菌
基因
生态学
遗传学
作者
Meta Kuehn,Nicole C. Kesty
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory Press]
日期:2005-11-15
卷期号:19 (22): 2645-2655
被引量:917
摘要
Extracellular secretion of products is the major mechanism by which Gram-negative pathogens communicate with and intoxicate host cells. Vesicles released from the envelope of growing bacteria serve as secretory vehicles for proteins and lipids of Gram-negative bacteria. Vesicle production occurs in infected tissues and is influenced by environmental factors. Vesicles play roles in establishing a colonization niche, carrying and transmitting virulence factors into host cells, and modulating host defense and response. Vesicle-mediated toxin delivery is a potent virulence mechanism exhibited by diverse Gram-negative pathogens. The biochemical and functional properties of pathogen-derived vesicles reveal their potential to critically impact disease.
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