An optimal design for the stackable four-layered piezoelectric power generation device and its microelectric energy saving method is presented here. In this work, three different device arrangements for the piezoelectric four-layered power generation devices were firstly deposited and compared for obtaining a greater output power. Measurement results demonstrated that Sample 2 among the three different device arrangements could not only avoid the damage to PZT-5H piezoelectric materials but also achieve a grater instantaneous output power (5.359mW). Subsequently, a novel microelectric energy saving system by constructing a less power dissipation boost converter IC with its proper surrounding circuit was also exhibited. Evidence showed that among the three different IC modules, Case 1 performs an optimal microelectric energy saving system since it could effectively fully charge a 30 mAh Zn-MnO 2 battery within the shortest time duration (4 hours).